Science reveals how cow urine and DMSO could transform breast cancer treatment

By oliviacook // 2025-04-27

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Compounds from cow urine, specifically free fatty acids (FFAs), show promise in fighting breast cancer by targeting cancer cells while sparing healthy ones.
DMSO (dimethyl sulfoxide) enhances the anticancer effect of FFAs by improving their delivery into cancer cells.
The combination of Cow Urine DMSO Fraction (CUDF) and DMSO specifically targets cancer cells without harming normal cells, offering a safe alternative to traditional treatments.
FFAs found in CUDF inhibit histone deacetylases, (HDACs), enzymes responsible for cancer cell growth and survival, triggering apoptosis (programmed cell death) in tumors.
This study truly opens the door for further exploration of naturally targeted cancer treatments, potentially revolutionizing the way we treat breast cancer and other cancers in the future.

In a groundbreaking study published in Biomedicines in February 2023, researchers have uncovered a promising natural compound derived from cow urine that could offer a safer, more effective way to fight breast cancer. The secret lies in a combination of cow urine's free fatty acids (FFAs) and DMSO (dimethyl sulfoxide), a natural compound long known for its ability to penetrate cell membranes and enhance the effectiveness of other substances. But what makes this discovery so remarkable is that the combination of these natural compounds may hold the key to fighting cancer while leaving healthy cells untouched. Breast cancer continues to be one of the leading causes of cancer-related deaths among women, claiming over 6.1 million lives annually worldwide. Despite significant advances in treatment, many patients still face significant challenges, including the development of drug resistance, the recurrence of tumors and severe side effects from chemotherapy. In the search for better therapies, researchers are increasingly looking to natural compounds that could offer a more selective, less toxic alternative. Traditional cancer treatments such as chemotherapy work by attacking rapidly dividing cells, but they also harm healthy cells, leading to debilitating side effects, like fatigue, nausea and weakened immunity. This is where the potential of cow urine and DMSO comes in – a combination that targets cancer cells while sparing the healthy ones, potentially providing a safer and more effective treatment option.

The role of DMSO and cow urine

DMSO has long been used in medical research for its unique ability to carry other compounds into cells, improving their effectiveness. It has demonstrated anti-inflammatory and anticancer properties in its own right but until now, its potential in combination with natural substances, like cow urine, has remained largely unexplored. The researchers in this study focused on a specific extract from cow urine, known as the Cow Urine DMSO Fraction (CUDF), which contains a range of bioactive compounds, including free fatty acids (FFAs). These FFAs have been found to play an important role in the regulation of cancer cell growth. By combining the CUDF with DMSO, the researchers were able to enhance the delivery of these bioactive compounds into the cancer cells, allowing them to exert a more potent effect. The researchers tested the CUDF on two types of breast cancer cells, MCF-7 and ZR-75-1 and the results were striking. At a concentration of 50 micrograms per milliliter (µg/mL). CUDF treatment led to a significant reduction in the viability of cancer cells:

The MCF-7 cells saw an almost 42 percent reduction in cell viability.
The ZR-75-1 cells showed a 34 percent reduction.

This finding is particularly significant because it suggests that CUDF, combined with DMSO, has the ability to slow or even halt the growth of breast cancer cells in a controlled manner. Furthermore, the study demonstrated that CUDF induced apoptosis or programmed cell death in the cancer cells – a crucial mechanism for eliminating damaged or abnormal cells. The researchers observed telltale signs of apoptosis, including chromatin condensation and the formation of apoptotic bodies in the treated cells. This indicates that CUDF and DMSO not only hinder the growth of cancer cells but also effectively trigger their self-destruction, which is a hallmark of effective cancer treatments.

A safer alternative: Selectivity for cancer cells

One of the most exciting aspects of this study is the selectivity of the CUDF and DMSO treatment. In testing with human gingival mesenchymal stem cells (hGMSCs), which are health cells from the mouth, the researchers found that CUDF did not cause any cell death or toxicity. This suggests that the combination of cow urine and DMSO could offer a highly targeted treatment option, capable of killing cancer cells without harming normal tissue. This selectivity is rare in cancer treatments, where most therapies affect both healthy and cancerous cells. The ability of CUDF and DMSO to specifically target cancer cells while sparing healthy ones represents a significant step forward in cancer therapy, offering hope for a treatment that is both effective and less toxic. To understand how CUDF and DMSO work on a molecular level, the researchers used cutting-edge technology to analyze the treatment's effects on the cancer cells. They identified several key FFAs, including tetracosanedioic acid, erucic acid (13Z-docosenoic acid) and nervonic acid, which were present in the cancer cells treated with CUDF. These FFAs were focused to inhibit histone deacetylases (HDACs), enzymes that are often over-expressed in cancer cells. HDACs are critical for the regulation of gene expression and their over-expression is associated with the uncontrolled growth and survival of cancer cells. By inhibiting HDACs, CUDF's FFAs may be able to disrupt the cancer cells' ability to grow and survive. The researchers also used advanced techniques, like molecular docking and molecular dynamics simulations to show that these FFAs, particularly tetracosanedioic acid, have a strong affinity for HDACs, suggesting that they could effectively block the cancer cells' ability to proliferate. While cow urine's FFAs are undoubtedly powerful, DMSO plays a crucial role in making this therapy effective. DMSO is known for its ability to penetrate cell membranes and it acts as a delivery vehicle, ensuring that the bioactive compounds in cow urine reach the cancer cells where they can have the most impact. This synergy between DMSO and CUDF enhances the anticancer properties of the natural compounds, making them more effective in fighting cancer. For decades, DMSO's full potential is unappreciated. This study shows that, when combined with natural extracts like those from cow urine, DMSO could provide a highly selective, powerful weapon against cancer. Although the research is still in its early stages, the implications are profound. If future studies confirm the findings and demonstrate the effectiveness of CUDF and DMSO in clinical settings, this could pave the way for a new class of natural cancer therapies. This combination of natural fatty acids and DMSO's delivery power could revolutionize the treatment of breast cancer and other cancers, offering a safer, more targeted approach, with fewer side effects. Watch this video about DMSO and its effects on collagen remodeling. This video is from the Daily Videos channel on Brighteon.com.

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The role of DMSO and cow urine

A safer alternative: Selectivity for cancer cells

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